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SMPD3 Antibody (PA5-143767) in WB
Western blot of SMPD3 in aldehyde-fixed and NP-40-permeabilized differentiated PC12 cells. The cells were labeled with rabbit SMPD3 polyclonal antibody (Product # PA5-143767) in the absence (Left) or presence (Right) of blocking peptide. The antibody was detected using appropriate secondary antibody conjugated to DyLight® 594. The cells were counterstained with Sytox green to label nuclei.
产品信息
PA5-143767
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
nSMase2 synthetic peptide corresponds to amino acids in the C-terminal region of human nSMase2. This sequence is highly conserved in rat and mouse nSMase2, and has low homology to other nSMase family members.
偶联物
形式
Liquid
浓度
~0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2942995
产品详细信息
The antibody detects a 78 kDa* band corresponding to nSMase2 on SDS-PAGE immunoblots of adult mouse brain and rat PC12 cells.
靶标信息
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: confluent 3Y1 cell-associated 1; Confluent 3Y1 cell-associated protein 1; neutral sphingomyelin phosphodiesterase 3; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; nSMase2; Sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
基因别名: 4631433G07Rik; AI427456; AW537966; Cca1; fro; NSMASE2; SMPD3
UniProt ID: (Human) Q9NY59, (Rat) O35049, (Mouse) Q9JJY3
Entrez Gene ID: (Human) 55512, (Rat) 94338, (Mouse) 58994
hematopoietic progenitor cell differentiation
sphingomyelin catabolic process
glycosphingolipid metabolic process
cell cycle
peptide hormone secretion
positive regulation of exosomal secretion
positive regulation of ceramide biosynthetic process
sphingolipid metabolic process
sphingomyelin metabolic process
multicellular organism development
lipid metabolic process
signal transduction
