Osenses

SMURF1 Polyclonal Antibody

产品信息

OSS00234W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:2,000

免疫组化 (IHC)

1:300-1:2,000

其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from internal region of mouse E3 ubiquitin protein ligase SMURF1 conjugated to an immunogenic carrier protein was used as the antigen

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: SMUF1.

靶标信息

Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e. g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The transcriptional landscape of the mammalian genome.

Science (New York, N.Y.)

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Fri Sep 02 00:00:00 UTC 2005

The DNA sequence of human chromosome 7.

Nature

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Thu Jul 10 00:00:00 UTC 2003

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DNA research : an international journal for rapid publication of reports on genes and genomes

Nagase T,Kikuno R,Nakayama M,Hirosawa M,Ohara O

Thu Aug 31 00:00:00 UTC 2000

生物信息学

蛋白别名: E3 ubiquitin ligase SMURF1; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; hSMURF1; hSMURF2; SMAD ubiquitination regulatory factor 1; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1

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基因别名: 4930431E10Rik; KIAA1625; mKIAA1625; RGD1309707; SMURF1

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UniProt ID: (Human) Q9HCE7, (Mouse) Q9CUN6

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Entrez Gene ID: (Human) 57154, (Rat) 690516, (Mouse) 75788

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功能