Invitrogen

SNAIL Polyclonal Antibody

SNAIL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SNAIL Antibody (PA5-11923) in IHC (P)

Immunohistochemistry analysis of SNAIL in formalin-fixed and paraffin-embedded Human spleen tissue. Samples were incubated with SNAIL polyclonal antibody (Product # PA5-11923) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

SNAIL Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

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产品信息

PA5-11923

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化（石蜡） (IHC (P))

1:10-1:50

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免疫细胞化学 (ICC/IF)

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其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human SNAIL

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Size-exclusion - Dialysis, Ammonium sulfate precipitation

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_10985622

靶标信息

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

SLUG and SNAIL as Potential Immunohistochemical Biomarkers for Renal Cancer Staging and Survival.

International journal of molecular sciences

Zivotic M,Kovacevic S,Nikolic G,Mioljevic A,Filipovic I,Djordjevic M,Jovicic V,Topalovic N,Ilic K,Radojevic Skodric S,Dundjerovic D,Nesovic Ostojic J

Published figure using SNAIL polyclonal antibody (Product # PA5-11923) in Immunohistochemistry (Paraffin)

Mon Jul 31 00:00:00 UTC 2023

Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-β/Smad Axis Cascades.

Frontiers in pharmacology

Liu J,Miao X,Xiao B,Huang J,Tao X,Zhang J,Zhao H,Pan Y,Wang H,Gao G,Xiao GG

PA5-11923 was used in Western Blotting to study obg-like ATPase 1 in breast cancer chemoresistance.

Mon Sep 28 00:00:00 UTC 2020

Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-β/Smad Axis Cascades.

Frontiers in pharmacology

Liu J,Miao X,Xiao B,Huang J,Tao X,Zhang J,Zhao H,Pan Y,Wang H,Gao G,Xiao GG

PA5-11923 was used in Western Blotting to study obg-like ATPase 1 in breast cancer chemoresistance.

Mon Sep 28 00:00:00 UTC 2020

Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.

BMC molecular and cell biology

Liu J,Yang Q,Xiao KC,Dobleman T,Hu S,Xiao GG

Published figure using SNAIL polyclonal antibody (Product # PA5-11923) in Western Blot

Mon Sep 14 00:00:00 UTC 2020

Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond.

Cancer microenvironment : official journal of the International Cancer Microenvironment Society

Steinbichler TB,Savic D,Dejaco D,Romani A,Kofler B,Skvortsova II,Riechelmann H,Dudas J

PA5-11923 was used in Western Blot to analyse the effects of epithelial mesenchymal crosstalk (EMC) on head and neck cancer cells.

Sun Dec 01 00:00:00 UTC 2019

AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128.

Scientific reports

Eterno V,Zambelli A,Villani L,Tuscano A,Manera S,Spitaleri A,Pavesi L,Amato A

PA5-11923 was used in immunocytochemistry and western blot to assess the promotion of wnt3a stabilization through suppression of miR-128 by AurkA that controls self-renewal of breast cancer-initiating cells

Fri Jun 24 00:00:00 UTC 2016

AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128.

Scientific reports

Eterno V,Zambelli A,Villani L,Tuscano A,Manera S,Spitaleri A,Pavesi L,Amato A

Fri Jun 24 00:00:00 UTC 2016

A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial-mesenchymal transition-independent manner.

Hepatology (Baltimore, Md.)

Fang JH,Zhou HC,Zhang C,Shang LR,Zhang L,Xu J,Zheng L,Yuan Y,Guo RP,Jia WH,Yun JP,Chen MS,Zhang Y,Zhuang SM

PA5-11923 was used in immunohistochemistry (paraffin) to identify and characterize vessels that encapsulated tumor clusters in hepatocellular carcinoma sections.

Sat Aug 01 00:00:00 UTC 2015

生物信息学

蛋白别名: Protein sna; Protein snail homolog 1; Sna protein; snai; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; Zinc finger protein SNAI1

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基因别名: dJ710H13.1; SLUGH2; SNA; SNAH; SNAI1; SNAIL; SNAIL1

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UniProt ID: (Human) O95863

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Entrez Gene ID: (Human) 6615

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功能

RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding kinase binding metal ion binding C2H2 zinc finger transcription factor

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