Product References
Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle for Myopathy but Does Not Cause Cachexia.
Pharmaceuticals (Basel, Switzerland)
Campelj DG,Timpani CA,Cree T,Petersen AC,Hayes A,Goodman CA,Rybalka E
MA1-745 was used in Western Blot to investigate the effects of a chemotherapeutic agent, 5-fluorouracil (5FU), on skeletal muscle mass and function, and whether small-molecule therapeutic candidate, BGP-15, could be protective against the chemotoxic challenge exerted by 5FU.
Mon May 17 00:00:00 UTC 2021
Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle for Myopathy but Does Not Cause Cachexia.
Pharmaceuticals (Basel, Switzerland)
Campelj DG,Timpani CA,Cree T,Petersen AC,Hayes A,Goodman CA,Rybalka E
MA1-745 was used in Western Blot to investigate the effects of a chemotherapeutic agent, 5-fluorouracil (5FU), on skeletal muscle mass and function, and whether small-molecule therapeutic candidate, BGP-15, could be protective against the chemotoxic challenge exerted by 5FU.
Mon May 17 00:00:00 UTC 2021
β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis.
The American journal of pathology
Ye R,Onodera T,Blanchard PG,Kusminski CM,Esser V,Brekken RA,Scherer PE
MA1-745 was used in Western Blotting to reveal, for the first time, that β1 syntrophin is a critical regulator of actin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective against cerulein-induced acute pancreatitis.
Mon Apr 01 00:00:00 UTC 2019
Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy.
Scientific reports
Sicca F,Ambrosini E,Marchese M,Sforna L,Servettini I,Valvo G,Brignone MS,Lanciotti A,Moro F,Grottesi A,Catacuzzeno L,Baldini S,Hasan S,D'Adamo MC,Franciolini F,Molinari P,Santorelli FM,Pessia M
MA1-745 was used in western blot investigate the role of Kir4.1 variants to autism-epilepsy comorbidity
Wed Sep 28 00:00:00 UTC 2016
Neuronal nitric oxide synthase localizes to utrophin expressing intercalated discs and stabilizes their structural integrity.
Neuromuscular disorders : NMD
Gonzalez JP,Crassous PA,Schneider JS,Beuve A,Fraidenraich D
MA1-745 was used in immunohistochemistry - frozen section to study the localization of neuronal nitric oxide synthase to utrophin expressing intercalated discs and stabilization of their structural integrity
Tue Dec 01 00:00:00 UTC 2015
PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.
Circulation
Shy D,Gillet L,Ogrodnik J,Albesa M,Verkerk AO,Wolswinkel R,Rougier JS,Barc J,Essers MC,Syam N,Marsman RF,van Mil AM,Rotman S,Redon R,Bezzina CR,Remme CA,Abriel H
MA1-745 was used in Western Blotting to demonstrate the significance of the PDZ domain-binding motif in the correct expression of NaV1.5, and the role of NaV1.5 in ventricular conduction.
Tue Jul 08 00:00:00 UTC 2014
Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism-epilepsy phenotype.
Human molecular genetics
Ambrosini E,Sicca F,Brignone MS,D'Adamo MC,Napolitano C,Servettini I,Moro F,Ruan Y,Guglielmi L,Pieroni S,Servillo G,Lanciotti A,Valvo G,Catacuzzeno L,Franciolini F,Molinari P,Marchese M,Grottesi A,Guerrini R,Santorelli FM,Priori S,Pessia M
MA1-745 was used in western blot to study a naturally occurring Kir2.1 mutation associated with short QT3 syndrome and autism-epilepsy
Mon Sep 15 00:00:00 UTC 2014
Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1.
Cancer science
Makokha GN,Takahashi M,Higuchi M,Saito S,Tanaka Y,Fujii M
MA1-745 was used in western blot to study the subcellular mislocalization of MAGI-1 by the Tax oncoprotein of HTLV-1 and the significance for the persistence of HTLV-1 infection
Fri Mar 01 00:00:00 UTC 2013
Phosphorylation on threonine 11 of β-dystrobrevin alters its interaction with kinesin heavy chain.
The FEBS journal
Fratini F,Macchia G,Torreri P,Matteucci A,Salzano AM,Crescenzi M,Macioce P,Petrucci TC,Ceccarini M
MA1-745 was used in western blot to study the role of beta-dystrobrevin threonine 11 phosphorylation in modulating its interaction with the kinesin heavy chain
Thu Nov 01 00:00:00 UTC 2012
Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.
The Journal of biological chemistry
Lien CF,Mohanta SK,Frontczak-Baniewicz M,Swinny JD,Zablocka B,Górecki DC
MA1-745 was used in western blot to investigate the role of glial alpha-dystrobrevin in the breakdown of the blood-brain barrier and progressive brain edema
Fri Nov 30 00:00:00 UTC 2012
Knockdown of MLC1 in primary astrocytes causes cell vacuolation: a MLC disease cell model.
Neurobiology of disease
Duarri A,Lopez de Heredia M,Capdevila-Nortes X,Ridder MC,Montolio M,López-Hernández T,Boor I,Lien CF,Hagemann T,Messing A,Gorecki DC,Scheper GC,Martínez A,Nunes V,van der Knaap MS,Estévez R
MA1-745 was used in immunocytochemistry to develop a model of megalencephalic leukoencephalopathy with subcortical cysts (MLC) disease
Fri Jul 01 00:00:00 UTC 2011
The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis.
Human molecular genetics
Brignone MS,Lanciotti A,Macioce P,Macchia G,Gaetani M,Aloisi F,Petrucci TC,Ambrosini E
Published figure using SNTB2 monoclonal antibody (Product # MA1-745) in Western Blot
Sat Jan 01 00:00:00 UTC 2011
Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice.
PloS one
Beck AJ,Vitale JM,Zhao Q,Schneider JS,Chang C,Altaf A,Michaels J,Bhaumik M,Grange R,Fraidenraich D
MA1-745 was used in western blot to evaluate the stem cell therapy for muscular dystrophy mice
Fri Oct 21 00:00:00 UTC 2011
A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes.
PloS one
Noël G,Stevenson S,Moukhles H
MA1-745 was used in western blot to identify chemical modulators for laminin-induced clustering of dystroglycan and aquaporin-4
Mon Mar 07 00:00:00 UTC 2011
MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation.
Neurobiology of disease
Lanciotti A,Brignone MS,Camerini S,Serafini B,Macchia G,Raggi C,Molinari P,Crescenzi M,Musumeci M,Sargiacomo M,Aloisi F,Petrucci TC,Ambrosini E
MA1-745 was used in western blot to study the role of caveolin-1 and phosphorylation in modulating the expression and trafficing of the MLC1 membrane protein
Mon Mar 01 00:00:00 UTC 2010
Synaptic localization of neuroligin 2 in the rodent retina: comparative study with the dystroglycan-containing complex.
Journal of neuroscience research
Lui L,Levinson JN,Noël G,Handrigan GR,Richman JM,El-Husseini A,Moukhles H
MA1-745 was used in immunohistochemistry to determine the localization of neuroligin 2 in rodent retinal synapses
Mon Mar 01 00:00:00 UTC 2010
The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.
Biochemical and biophysical research communications
Yamashita K,Suzuki A,Satoh Y,Ide M,Amano Y,Masuda-Hirata M,Hayashi YK,Hamada K,Ogata K,Ohno S
MA1-745 was used in western blot to investigate the mechanism of the interaction between utrophin and kinase PAR-1b
Fri Jan 01 00:00:00 UTC 2010
Dystrophin-associated protein scaffolding in brain requires alpha-dystrobrevin.
Neuroreport
Bragg AD,Das SS,Froehner SC
MA1-745 was used in immunohistochemistry to investigate the role of alpha-dystrobrevin in brain protein scaffolding
Wed Jul 14 00:00:00 UTC 2010
Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice.
PloS one
Stillwell E,Vitale J,Zhao Q,Beck A,Schneider J,Khadim F,Elson G,Altaf A,Yehia G,Dong JH,Liu J,Mark W,Bhaumik M,Grange R,Fraidenraich D
MA1-745 was used in immunohistochemistry and western blot to study the rescue of mdx mice by wild type embryonic stem cells
Thu Jul 02 00:00:00 UTC 2009
Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice.
PloS one
Stillwell E,Vitale J,Zhao Q,Beck A,Schneider J,Khadim F,Elson G,Altaf A,Yehia G,Dong JH,Liu J,Mark W,Bhaumik M,Grange R,Fraidenraich D
MA1-745 was used in immunohistochemistry and western blot to study the rescue of mdx mice by wild type embryonic stem cells
Thu Jul 02 00:00:00 UTC 2009
Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.
Circulation research
Gavillet B,Rougier JS,Domenighetti AA,Behar R,Boixel C,Ruchat P,Lehr HA,Pedrazzini T,Abriel H
MA1-745 was used in western blot to investigate the role of syntrophins and dystrophin on the proper expression and function of Na (v) 1.5
Fri Aug 18 00:00:00 UTC 2006
Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.
The Journal of biological chemistry
Chen Z,Hague C,Hall RA,Minneman KP
MA1-745 was used in immunoprecipitation to study the mechanism for syntrophin regulation of alpha1D-adrenergic receptors .
Fri May 05 00:00:00 UTC 2006
Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.
The Journal of biological chemistry
Chen Z,Hague C,Hall RA,Minneman KP
MA1-745 was used in immunoprecipitation to study the mechanism for syntrophin regulation of alpha1D-adrenergic receptors .
Fri May 05 00:00:00 UTC 2006
Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
The EMBO journal
Ort T,Voronov S,Guo J,Zawalich K,Froehner SC,Zawalich W,Solimena M
Published figure using SNTB2 monoclonal antibody (Product # MA1-745) in Western Blot
Wed Aug 01 00:00:00 UTC 2001
Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.
The Journal of cell biology
Adams ME,Kramarcy N,Krall SP,Rossi SG,Rotundo RL,Sealock R,Froehner SC
MA1-745 was used in immunoprecipitation to investigate the impacts of the lack of alpha-syntrophin on neuromuscular synapses
Mon Sep 18 00:00:00 UTC 2000
A role of tyrosine phosphatase in acetylcholine receptor cluster dispersal and formation.
The Journal of cell biology
Dai Z,Peng HB
MA1-745 was used in immunocytochemistry to investigate the regulation of AChR cluster dispersal and formation by PTPase
Mon Jun 29 00:00:00 UTC 1998
