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产品信息
22938-MSM2-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
PCRP-SNW1-2A1
抗原
Recombinant fragment of human SNW1 protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control:HeLa or U87 cells. General nuclear expression.
Cellular Location: Nucleus. Cytosol.
靶标信息
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of Drosophila BX42; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; PPS; SKI interacting protein; SKI-interacting protein; SNW domain-containing protein 1
基因别名: Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1
UniProt ID: (Human) Q13573
Entrez Gene ID: (Human) 22938
transcription coactivator activity
transcription corepressor activity
Notch binding
protein binding
nuclear hormone receptor binding
vitamin D receptor binding
retinoic acid receptor binding
poly(A) RNA binding
SMAD binding
RNA metabolism protein
RNA processing factor
RNA splicing factor
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
mRNA splicing, via spliceosome
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
Notch signaling pathway
viral process
positive regulation of transforming growth factor beta receptor signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mRNA splicing, via spliceosome
retinoic acid receptor signaling pathway
regulation of retinoic acid receptor signaling pathway
positive regulation of neurogenesis
positive regulation of histone H3-K4 methylation
regulation of vitamin D receptor signaling pathway
positive regulation of vitamin D receptor signaling pathway
cellular response to retinoic acid
