Invitrogen

SNX6 Polyclonal Antibody

SNX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SNX6 Antibody (PA5-115946) in IHC (P)

Immunohistochemistry analysis of SNX6 in human colorectal cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115946) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.

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产品信息

PA5-115946

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human SNX6(Accession Q9UNH7), corresponding to amino acid residues F216-F266.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2900580

产品详细信息

Antibody detects endogenous levels of total Snx6.

靶标信息

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase.

Cell reports

Royero P,Quatraccioni A,Früngel R,Silva MH,Bast A,Ulas T,Beyer M,Opitz T,Schultze JL,Graham ME,Oberlaender M,Becker A,Schoch S,Beck H

PA5-115946 was used in Immunohistochemistry (PFA fixed), Western Blot to identify a mechanism for cell-autonomous regulation of a specific inhibitory circuit that is critical to ensure that a majority of cortical pyramidal cells participate in information coding.