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产品信息
PA5-120985
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SOAT1 (NP_003092.4).
偶联物
形式
Liquid
浓度
1.03 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914557
产品详细信息
Positive test controls include: H460, HeLa, SW480, Mouse stomach, Mouse liver, Rat liver, Rat stomach. The target is usually found in the following locations: Endoplasmic reticulum membrane, Multi-pass membrane protein.
Immunogen sequence: MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK IFIARRSLLD
靶标信息
SOAT1 (sterol O-acyltransferase-1), also designated ACAT1, is a homotetra-meric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A (acyl-CoA). The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol O-acyltransferase-2), also known as ACAT2 (acyl-CoA:cholesterol acyltransferase-2), participates in lipo-protein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACAT-1; acyl coenzyme A:cholesterol acyltransferase 1; Acyl-coenzyme A:cholesterol acyltransferase 1; adrenocortical lipid depletion; Cholesterol acyltransferase 1; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1; Sterol O-acyltransferase 1
基因别名: 8430426K15Rik; ACACT; ACACT1; ACAT; ACAT-1; ACAT1; ald; AW550831; hid; SOAT; SOAT1; STAT
UniProt ID: (Human) P35610, (Mouse) Q61263, (Rat) O70536
Entrez Gene ID: (Human) 6646, (Mouse) 20652, (Rat) 81782
cholesterol metabolic process
macrophage derived foam cell differentiation
cholesterol storage
cholesterol efflux
very-low-density lipoprotein particle assembly
cholesterol esterification
cholesterol homeostasis
positive regulation of amyloid precursor protein biosynthetic process
lipid metabolic process
steroid metabolic process
