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SOCS2 Antibody (PA5-119445) in IHC (P)
Immunohistochemistry analysis of SOCS2 in paraffin-embedded Rat Cardiac Muscle tissue. Samples were incubated with polyclonal antibody (Product # PA5-119445) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-119445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Suppressors Of Cytokine Signaling 2. The antigen corresponds to amino acid range 1-198 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903943
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine inducible SH2-containing protein 2; Cytokine-inducible SH2 protein 2; SOCS-2; Suppressor of cytokine signaling 2
Gene Aliases: Cish2; Socs-2; Socs2
UniProt ID: (Rat) O88582
Entrez Gene ID: (Rat) 84607
regulation of cell growth
negative regulation of protein kinase activity
aging
lactation
protein ubiquitination
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
intracellular signal transduction
regulation of multicellular organism growth
negative regulation of multicellular organism growth
response to peptide hormone
positive regulation of neuron differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
growth hormone receptor signaling pathway
mammary gland alveolus development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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