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Invitrogen
SOCS2 Polyclonal Antibody
FIGURE: 1 / 5
SOCS2 Antibody (PA5-17219) in WB
Western blot was performed using Anti-SOCS2 Polyclonal Antibody (Product # PA5-17219) and a 22kDa band corresponding to SOCS2 was observed across cell lines tested except U-2 OS and Jurkat which are reported to be negative for SOCS2 expression. Whole cell extracts (30 µg lysate) of K-562 (Lane 1), Caco-2 (Lane 2), PC-3 (Lane 3), HCT 116 (Lane 4), U-2 OS (Lane 5) and Jurkat (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Pro... View More
Product Details
PA5-17219
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues at the carboxyl terminus of human SOCS2
Conjugate
Form
Liquid
Concentration
374 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10979935
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CIS-2; cytokine inducible SH2-containing protein 2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; Suppressor of cytokine signaling 2; suppressor of cytokine signaling-2
Gene Aliases: 8030460M17; AI527257; AW108012; CIS2; Cish2; D130043N08Rik; hg; JAB; SOCS-2; SOCS2; SSI-2; SSI2; STATI2
UniProt ID: (Human) O14508, (Mouse) O35717, (Rat) O88582
Entrez Gene ID: (Human) 8835, (Mouse) 216233, (Rat) 84607
regulation of cell growth
negative regulation of protein kinase activity
JAK-STAT cascade
regulation of signal transduction
positive regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
negative regulation of apoptotic process
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
growth hormone receptor signaling pathway
lactation
negative regulation of signal transduction
intracellular signal transduction
regulation of growth
regulation of multicellular organism growth
negative regulation of multicellular organism growth
positive regulation of neuron differentiation
mammary gland alveolus development
aging
response to peptide hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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