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SOCS4 Antibody (PA5-119933) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of SOCS4 in Hela cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 10% negative goat serum for 15 minutes at room temperature. Cells were probed with SOCS4 Polyclonal Antibody (Product # PA5-119933) at a dilution of 1:200 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 conjugate-Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI... View More
产品信息
PA5-119933
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within human SOCS4 aa 391-440
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913505
产品详细信息
Positive Control: Rat brain tissue lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, Hela, human colon carcinoma tissue.
Subcellular Location: Phosphatidylinositol 3-kinase complex.
靶标信息
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SH2 domain containing SOCS box protein; SOCS-4; SOCS-7; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 7; suppressor of cytokine signalling 4
基因别名: 3110032M18Rik; A730004F22Rik; AI427843; AU015727; AU015859; SOCS4; SOCS7
UniProt ID: (Human) Q8WXH5, (Mouse) Q91ZA6
Entrez Gene ID: (Human) 122809, (Rat) 305828, (Mouse) 67296
negative regulation of epidermal growth factor-activated receptor activity
protein ubiquitination
cytokine-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
regulation of growth
negative regulation of JAK-STAT cascade
negative regulation of protein kinase activity
biological_process
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of signal transduction
