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SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
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蛋白别名: Amyotrophic lateral sclerosis 1 (ALS1); Cu/Zn SOD; CuZn superoxide dismutase; HGNC:11179; Indophenoloxidase A (IPOA); superoxide dismutase; Superoxide Dismutase 1 (SOD1); superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]
基因别名: SOD1
UniProt ID: (Rabbit) P09212
Entrez Gene ID: (Rabbit) 100009313