Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 5
SORL1 (extracellular) Antibody (ANR-132-200UL) in IHC (F)
Expression of SORL1 in mouse hippocampus. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-SORL1 (extracellular) Antibody (#ANR-132), (1:300), followed by goat Anti-rabbit-AlexaFluor-488. A. Staining in mouse hippocampal CA1 region revealed SORL1 immunoreactivity (green) in neuronal profiles in the pyramidal layer (P) and in the stratum oriens (SO, arrows). B. Pre-incuba... View More
Product Details
ANR-132-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KRRTPHAT(S)FNGED, corresponding to amino acid residues 652-665 of human SORL1, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ21930; FLJ39258; Gp250; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mosaic protein LR11; mSorLA; SorLA; SorLA-1; Sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; Sorting protein-related receptor containing LDLR class A repeats
Gene Aliases: 2900010L19Rik; AI596264; AW261561; C11orf32; gp250; LR11; LRP9; mSorLA; RGD619914; SORL1; SORLA; SorLA-1
UniProt ID: (Human) Q92673, (Rat) P0DSP1, (Mouse) O88307
Entrez Gene ID: (Human) 6653, (Rat) 300652, (Mouse) 20660
protein targeting to Golgi
protein targeting
protein targeting to lysosome
lipid transport
post-Golgi vesicle-mediated transport
receptor-mediated endocytosis
signal transduction
cholesterol metabolic process
regulation of smooth muscle cell migration
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of MAP kinase activity
protein retention in Golgi apparatus
positive regulation of protein catabolic process
negative regulation of neurogenesis
protein maturation
positive regulation of protein exit from endoplasmic reticulum
negative regulation of neuron death
negative regulation of beta-amyloid formation
positive regulation of choline O-acetyltransferase activity
negative regulation of tau-protein kinase activity
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of early endosome to recycling endosome transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of protein localization to early endosome
negative regulation of neurofibrillary tangle assembly
positive regulation of endocytic recycling
cell proliferation
cell migration
lipid metabolic process
transport
endocytosis
multicellular organism development
steroid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support