Invitrogen

SP1 Polyclonal Antibody

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抗体检测数据 (1)

SP1 Antibody in Western Blot (WB)

SP1 Antibody in Western Blot (WB)

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SP1 Antibody (PA5-142435) in WB

Western Blot analysis of SP1 in NIH3T3 nuclear lysate (35 µg protein in RIPA buffer) using SP1 Polyclonal Antibody (Product # PA5-142435) at 0.3 µg/mL incubated for 1 hour. Detected by chemiluminescence.

SP1 Antibody in Western Blot (WB)

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SP1 Antibody in Western Blot (WB) — Western Blot analysis of SP1 in NIH3T3 nuclear lysate (35 µg protein in RIPA buffer) using SP1 Polyclonal Antibody (Product # PA5-142435) at 0.3 µg/mL incubated for 1 hour. Detected by chemiluminescence.

产品信息

PA5-142435

应用

建议稀释比

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免疫印迹 (WB)

0.3-1 µg/mL

-

产品规格

种属反应

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence C-DGIHDETAGGEGEN.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2933083

产品详细信息

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.

靶标信息

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HGNC:11205; Specificity protein 1; Transcription factor Sp1

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基因别名: 1110003E12Rik; AA450830; AI845540; Sp1; Sp1-1

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UniProt ID: (Mouse) O89090

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Entrez Gene ID: (Mouse) 20683

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding transcription factor binding histone acetyltransferase binding enhancer binding protein homodimerization activity histone deacetylase binding bHLH transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding HMG box domain binding C2H2 zinc finger transcription factor

ossification in utero embryonic development trophectodermal cell differentiation liver development embryonic placenta development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter megakaryocyte differentiation lung development enucleate erythrocyte differentiation positive regulation by host of viral transcription positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process embryonic camera-type eye morphogenesis embryonic skeletal system development embryonic process involved in female pregnancy definitive hemopoiesis