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产品信息
MA5-20003
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4E5
抗原
SP3 (NP_003102, 287 a.a. ~ 430 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608151
产品详细信息
Peptide Sequence: TAGINADGHL INTGQAMDSS DNSERTGERV SPDINETNTD TDLFVPTSSS SQLPVTIDST GILQQNTNSL TTSSGQVHSS DLQGNYIQSP VSEETQAQNI QVSTAQPVVQ HLQLQESQQP TSQAQIVQGI TPQTIHGVQA SGQN*
靶标信息
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686O1631; GC-binding transcription factor Sp3; specificity protein 3; SPR-1; SPR-2; SPR1; trans-acting transcription factor 3; Transcription factor Sp3
基因别名: D130027J01Rik; SP3; SPR2
UniProt ID: (Human) Q02447, (Mouse) O70494
Entrez Gene ID: (Human) 6670, (Mouse) 20687, (Rat) 367846
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
metal ion binding
nucleic acid binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
natural killer cell differentiation
trophectodermal cell differentiation
liver development
embryonic placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
protein sumoylation
B cell differentiation
T cell differentiation
megakaryocyte differentiation
monocyte differentiation
lung development
granulocyte differentiation
enucleate erythrocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
embryonic skeletal system development
embryonic process involved in female pregnancy
definitive hemopoiesis
in utero embryonic development
transcription from RNA polymerase II promoter
erythrocyte differentiation
