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SPAG5 Antibody (PA5-35986) in ICC/IF
SPAG5 Polyclonal Antibody detects SPAG5 protein at spindle by immunofluorescent analysis. Sample: HeLa cells were fixed in 100% MeOH for 5 min. Green: SPAG5 protein stained by SPAG5 Polyclonal Antibody (Product # PA5-35986) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-35986
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 64 and 314 of SPAG5
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2553296
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2, NT2D1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Astrin; Deepest; MAP126; mitotic spindle associated protein p126; mitotic spindle coiled-coil related protein; Mitotic spindle-associated protein p126; Sperm-associated antigen 5
基因别名: DEEPEST; hMAP126; MAP126; SPAG5
UniProt ID: (Human) Q96R06
Entrez Gene ID: (Human) 10615
