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产品信息
H00025803-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
4A5
抗原
SPDEF (NP_036523, 92 a.a. approximately 200 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: QCPVIDSQAP AGSLDLVPGG LTLEEHSLEQ VQSMVVGEVL KDIETACKLL NITADPMDWS PSNVQKWLLW TEHQYRLPPM GKAFQELAGK ELCAMSEEQF RQRSPLGGD
靶标信息
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; SAM pointed domain-containing Ets transcription factor
基因别名: bA375E1.3; PDEF; PSE; SPDEF
UniProt ID: (Human) O95238
Entrez Gene ID: (Human) 25803
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
negative regulation of cell fate commitment
positive regulation of cell fate commitment
cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
lung goblet cell differentiation
intestinal epithelial cell development
