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SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Spartin; Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1
基因别名: KIAA0610; SPART; SPARTIN; SPG20; TAHCCP1
UniProt ID: (Human) Q8N0X7
Entrez Gene ID: (Human) 23111