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产品信息
PA5-28584
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 220 of Human SPHK1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546060
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Human (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Acetyltransferase SPHK1; RP23-193A16.4; SK 1; SKase; Sphingosine kinase 1; SPK 1
基因别名: SK1; SPHK; SPHK1; SPK
UniProt ID: (Human) Q9NYA1
Entrez Gene ID: (Human) 8877
blood vessel development
positive regulation of neurotransmitter secretion
sphingosine-1-phosphate signaling pathway
protein folding
sphingosine metabolic process
inflammatory response
signal transduction
brain development
female pregnancy
cellular response to starvation
positive regulation of peptidyl-threonine phosphorylation
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
response to amine
cyclooxygenase pathway
calcium-mediated signaling
sphingolipid biosynthetic process
positive regulation of cell growth
positive regulation of cell migration
positive regulation of protein ubiquitination
response to magnesium ion
response to progesterone
regulation of interleukin-1 beta production
response to ATP
intracellular signal transduction
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
positive regulation of angiogenesis
positive regulation of mitotic cell cycle
positive regulation of smooth muscle contraction
sphingosine biosynthetic process
sphingoid catabolic process
lipid phosphorylation
positive regulation of fibroblast proliferation
positive regulation of NF-kappaB transcription factor activity
cellular response to hydrogen peroxide
response to interleukin-1
cellular response to growth factor stimulus
