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产品信息
PA5-37458
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 496-543 of human LEKTI
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2554072
产品详细信息
This antibody detects endogenous protein at a molecular weight of 130 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.
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生物信息学
蛋白别名: ISK5; LEKTI; Lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; Serine protease inhibitor Kazal-type 5
基因别名: LEKTI; LETKI; NETS; NS; SPINK5; VAKTI
UniProt ID: (Human) Q9NQ38
Entrez Gene ID: (Human) 11005
negative regulation of antibacterial peptide production
epidermal cell differentiation
negative regulation of angiogenesis
extracellular matrix organization
epithelial cell differentiation
hair cell differentiation
anagen
regulation of T cell differentiation
negative regulation of immune response
negative regulation of serine-type endopeptidase activity
