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Immunogen sequence: KFWKGNSYQMM DHLDCATNEE NPVISGEQIV QQ
Highest antigen sequence identity to the following orthologs - mouse 79%, rat 73%.
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: IMP-3; intramembrane cleaving protease; Intramembrane protease 3; Presenilin-like protein 2; Signal peptide peptidase-like 2A; SPP-like 2A; SPPL2a protein
基因别名: IMP3; PSEC0147; PSL2; SPPL2A
UniProt ID: (Human) Q8TCT8
Entrez Gene ID: (Human) 84888