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SPPL3 Antibody (PA5-113253) in WB
Western blot analysis of SPPL3 in multiple sample types using a SPPL3 polyclonal antibody (Product # PA5-113253) at a dilution of 1:2,000. A goat anti rabbit polyclonal secondary antibody was used at a dilution of 1:50,000. Sample types that were tested include: Hela whole cell lysate, U87 whole cell lysate, SY5Y whole cell lysate, A549 whole cell lysate, HL-60 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate, mouse brain tissue, and rat brain tissue.
产品信息
PA5-113253
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
偶联物
形式
Liquid
浓度
0.99 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867987
靶标信息
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IMP-2; Intramembrane protease 2; Presenilin homologous protein 1; Presenilin-like protein 4; PSH1; signal peptide peptidase 3; signal peptide peptidase like 3; Signal peptide peptidase-like 3; signal peptide peptidase-like 3, pseudogene 1; SPP-like 3; SPP-like 3 protein; upregulated during skeletal muscle growth 3
基因别名: 4833416I09Rik; IMP2; MDHV1887; PRO4332; PSH1; PSL4; RGD1562826; SPPL3; Sppl3-ps1; Usmg3
UniProt ID: (Human) Q8TCT6, (Mouse) Q9CUS9
Entrez Gene ID: (Human) 121665, (Mouse) 74585, (Rat) 360822
signal peptide processing
membrane protein ectodomain proteolysis
positive regulation of cytosolic calcium ion concentration
positive regulation of protein binding
membrane protein proteolysis
positive regulation of protein dephosphorylation
T cell receptor signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of calcineurin-NFAT signaling cascade
proteolysis
