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产品信息
PA5-64897
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664175
产品详细信息
Immunogen sequence: FNSNVMVKVAT QPADNPLDVL SRKLHLGPNV GRDVPRLSLP GKLVFPSSTG
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IMP-2; Intramembrane protease 2; Presenilin homologous protein 1; Presenilin-like protein 4; PSH1; Signal peptide peptidase-like 3; SPP-like 3
基因别名: IMP2; MDHV1887; PRO4332; PSH1; PSL4; SPPL3
UniProt ID: (Human) Q8TCT6
Entrez Gene ID: (Human) 121665
signal peptide processing
membrane protein ectodomain proteolysis
positive regulation of cytosolic calcium ion concentration
positive regulation of protein binding
membrane protein proteolysis
positive regulation of protein dephosphorylation
T cell receptor signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of calcineurin-NFAT signaling cascade
