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产品信息
PA5-46262
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human SPRTN (aa 426-475).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2605525
产品详细信息
Peptide sequence: QIKSSGNDPK YSTTTAQNSS SSSSQSKMVN CPVCQNEVLE SQINEHLDWC
Sequence homology: Human: 100%
靶标信息
SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DNA-dependent metalloprotease SPRTN; DVC1; Protein with SprT-like domain at the N terminus; Spartan; zinc finger RAD18 domain-containing protein
基因别名: C1orf124; DVC1; PRO4323; spartan; SPRTN; UNQ1880/PRO4323
UniProt ID: (Human) Q9H040
Entrez Gene ID: (Human) 83932
