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产品信息
PA5-98172
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human SPRY2 protein (2-97AA)
偶联物
形式
Liquid
浓度
3.7 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812786
靶标信息
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MGC23039; Protein sprouty homolog 2; Spry-2
基因别名: hSPRY2; IGAN3; sprouty2; SPRY2
UniProt ID: (Human) O43597, (Mouse) Q9QXV8
Entrez Gene ID: (Human) 10253, (Mouse) 24064
establishment of mitotic spindle orientation
sensory perception of sound
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of peptidyl-threonine phosphorylation
negative regulation of cell projection organization
positive regulation of peptidyl-serine phosphorylation
negative regulation of GTPase activity
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
inner ear morphogenesis
negative regulation of apoptotic process
negative regulation of MAP kinase activity
cell fate commitment
regulation of cell differentiation
negative regulation of Ras protein signal transduction
negative regulation of neurotrophin TRK receptor signaling pathway
positive regulation of protein kinase B signaling
lung growth
bud elongation involved in lung branching
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
multicellular organism development
regulation of signal transduction
lung development
branching morphogenesis of an epithelial tube
lung morphogenesis
respiratory system development
