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产品信息
PA5-21170
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the carboxy terminus of human SPRYD2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153374
产品详细信息
A suggested positive control is mouse heart tissue lysate.
PA5-21170 can be used with blocking peptide PEP-1284.
靶标信息
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2310076E16Rik; cardiomyopathy associated 5; Cardiomyopathy-associated protein 5; Dystrobrevin-binding protein 2; Genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; Myospryn; SPRY domain-containing protein 2; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; TRIM-like protein; tripartite motif-containing 76; Tripartite motif-containing protein 76
基因别名: 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; CMYA5; DTNBP2; SPRYD2; sr553; Srfsd; Tims; TRIM76
UniProt ID: (Human) Q8N3K9
Entrez Gene ID: (Human) 202333, (Rat) 688915, (Mouse) 76469
