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产品信息
PA5-96127
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SQLE (NP_0031202)
偶联物
形式
Liquid
浓度
2.06 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807929
产品详细信息
Positive Samples: SKOV3, Mouse liver, Mouse kidney, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein
Immunogen sequence: VSVSSHFVGF LMKNAPQFKA NHAELILANP SPVLIYQISS SETRVLVDIR GEMPRNLREY MVEKIYPQIP DHLKEPFLEA TDNSHLRSMP ASFLPPSSVK K
靶标信息
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ30795; SE; Squalene epoxidase; Squalene monooxygenase
基因别名: AI323792; ERG1; SQLE
UniProt ID: (Human) Q14534, (Mouse) P52019, (Rat) P52020
Entrez Gene ID: (Human) 6713, (Mouse) 20775, (Rat) 29230
