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产品信息
MA5-33380
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3D12
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815518
产品详细信息
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Functional Assay- This antibody is useful for neutralization of the biological activity of SR-BI. For neutralization of biological activity dilutions have to be made according to the amounts SR-BI to be inactivated.
靶标信息
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; SR-BI; SRB1
基因别名: Cd36l1; Scarb1; SR-B1; Srb1
UniProt ID: (Rat) P97943
Entrez Gene ID: (Rat) 25073
lipopolysaccharide binding
phosphatidylserine binding
lipopolysaccharide receptor activity
lipid transporter activity
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
membrane trafficking regulatory protein
endothelial cell proliferation
steroid biosynthetic process
androgen biosynthetic process
cholesterol catabolic process
lipid transport
receptor-mediated endocytosis
phagocytosis, recognition
cell adhesion
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
cholesterol transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
regulation of phagocytosis
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
