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SRC3 Antibody (MA1-845) in IHC (P)
Immunohistochemistry was performed on normal biopsies of deparaffinized Human pancreas tissue. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature and probed with a SRC3 monoclonal antibody (Product # MA1-845) at a diluti... View More
产品信息
MA1-845
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
AX15.3
抗原
GST fusion protein encoding amino acid residues 605-1294 of human AIB1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_325446
产品详细信息
MA1-845 detects amplified in breast cancer-1 (AIB1) in human cells.
MA1-845 has been successfully used in Western blot and immunoprecipitation, ChIP, and immunohistochemistry procedures. By Western blot, this antibody detects an ~155 kDa protein representing AIB1 from MCF-7 cell extract.
The MA1-845 immunizing peptide corresponds to amino acid residues 605-1294 of human AIB1.
靶标信息
AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ACTR; AIB-1; Amplified in breast cancer 1 protein; bHLHe42; CBP-interacting protein; Class E basic helix-loop-helix protein 42; MGC141848; NCoA-3; Nuclear receptor coactivator 3; OTTHUMP00000031716; pCIP; RAC-3; Receptor-associated coactivator 3; RP5-1049G16.3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRAM-1
基因别名: ACTR; AIB-1; AIB1; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1
UniProt ID: (Human) Q9Y6Q9
Entrez Gene ID: (Human) 8202
transcription coactivator activity
histone acetyltransferase activity
protein binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
thyroid hormone receptor binding
protein dimerization activity
protein N-terminus binding
androgen receptor binding
transcription, DNA-templated
positive regulation of gene expression
histone acetylation
androgen receptor signaling pathway
intracellular receptor signaling pathway
receptor transactivation
positive regulation of keratinocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to estradiol stimulus
regulation of RNA biosynthetic process
