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SREBP2 Antibody (SREBF-201AP) in WB
SREBP2 (SREBF-201AP) blotted with rat tissues: A. Liver B. Adrenal gland C. Testis SREBP2 is a transcription factor with three variants sized 135, 132 and 109 kDa. 1:250 antibody dilution in DiluOBuffer (FGI-1963) for 1 hour at room temperature on 10% SDS-PAGE gel.
Product Details
SREBF-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 640-690 on human Sterol regulatory element binding protein-2.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHd2; Class D basic helix-loop-helix protein 2; srebf2; srebf2 {ECO:0000312|EMBL:AAI01903.1}; SREBP-2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2
Gene Aliases: AI608257; BHLHD2; lop13; nuc; SREBF2; Srebf2_retired; SREBP-2; SREBP2; SREBP2gc
UniProt ID: (Human) Q12772, (Rat) Q3T1I5, (Mouse) Q3U1N2
Entrez Gene ID: (Human) 6721, (Rat) 300095, (Mouse) 20788
C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein C-terminus binding
protein dimerization activity
E-box binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
aging
cholesterol metabolic process
lipid biosynthetic process
response to hormone
response to lead ion
positive regulation of cholesterol storage
response to lipid
response to drug
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of cholesterol homeostasis
lipid metabolic process
cellular response to starvation
cellular response to laminar fluid shear stress
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
transcription from RNA polymerase II promoter
steroid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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