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产品信息
PA5-50888
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region derived from internal residues of human SLIT-ROBO Rho GTPase activating protein 2
偶联物
形式
Liquid
浓度
1.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636340
产品详细信息
The antibody detects endogenous levels of total SRGAP2 protein.
靶标信息
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FBP-27; formin binding protein 2; Formin-binding protein 2; Formin-binding protein 27; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
基因别名: 9930124L22Rik; AI448945; ARHGAP34; FBP2; Fbp27; FNBP2; KIAA0456; RGD1566016; SRGAP2; SRGAP2A; SRGAP3
UniProt ID: (Human) O75044, (Rat) D4A208, (Mouse) Q91Z67
Entrez Gene ID: (Human) 23380, (Rat) 360840, (Mouse) 14270
lamellipodium assembly involved in ameboidal cell migration
signal transduction
cell proliferation
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
regulation of small GTPase mediated signal transduction
negative regulation of cell death
dendritic spine development
negative regulation of neuron migration
negative regulation of cell migration
nervous system development
