Product References
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.
Nature communications
Ajiro M,Awaya T,Kim YJ,Iida K,Denawa M,Tanaka N,Kurosawa R,Matsushima S,Shibata S,Sakamoto T,Studer L,Krainer AR,Hagiwara M
33-9400 was used in Western Blot to indicate that small synthetic molecules affecting phosphorylation state of SRSFs is available as a new therapeutic modality for mechanism-oriented precision medicine of splicing diseases.
Fri Jul 23 00:00:00 UTC 2021
Splicing Enhancers at Intron-Exon Borders Participate in Acceptor Splice Sites Recognition.
International journal of molecular sciences
Kováčová T,Souček P,Hujová P,Freiberger T,Grodecká L
33-9400 was used in Western Blotting to analyse 3'splice site recognition where the intron-exon border is bound by a ubiquitous splicing regulator SRSF1.
Tue Sep 08 00:00:00 UTC 2020
Splicing Enhancers at Intron-Exon Borders Participate in Acceptor Splice Sites Recognition.
International journal of molecular sciences
Kováčová T,Souček P,Hujová P,Freiberger T,Grodecká L
33-9400 was used in Western Blotting to analyse 3'splice site recognition where the intron-exon border is bound by a ubiquitous splicing regulator SRSF1.
Tue Sep 08 00:00:00 UTC 2020
Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
EMBO molecular medicine
Iwai K,Yaguchi M,Nishimura K,Yamamoto Y,Tamura T,Nakata D,Dairiki R,Kawakita Y,Mizojiri R,Ito Y,Asano M,Maezaki H,Nakayama Y,Kaishima M,Hayashi K,Teratani M,Miyakawa S,Iwatani M,Miyamoto M,Klein MG,Lane W,Snell G,Tjhen R,He X,Pulukuri S,Nomura T
33-9400 was used in Western Blotting to identify that T-025 functions as an orally available and potent inhibitor of Cdc2-like kinases, evolutionally conserved kinases that facilitate exon recognition in the splicing machinery.
Fri Jun 01 00:00:00 UTC 2018
Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.
Retrovirology
Erkelenz S,Hillebrand F,Widera M,Theiss S,Fayyaz A,Degrandi D,Pfeffer K,Schaal H
33-9400 was used in western blot to investigate viral tat-mRNA splicing.
Sat Mar 28 00:00:00 UTC 2015
Digoxin suppresses HIV-1 replication by altering viral RNA processing.
PLoS pathogens
Wong RW,Balachandran A,Ostrowski MA,Cochrane A
33-9400 was used in western blot to examine the effects of RNA splicing modulators on viral RNA metabolism
Fri Mar 01 00:00:00 UTC 2013
Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.
The Journal of biological chemistry
Walsh CM,Suchanek AL,Cyphert TJ,Kohan AB,Szeszel-Fedorowicz W,Salati LM
33-9400 was used in ChIP assay and western blot to report that nutrients and hormones control the activity of serine-arginine-rich proteins which regulate the splicing of G6PD mRNA.
Fri Jan 25 00:00:00 UTC 2013
Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.
The Journal of biological chemistry
Walsh CM,Suchanek AL,Cyphert TJ,Kohan AB,Szeszel-Fedorowicz W,Salati LM
33-9400 was used in ChIP assay and western blot to report that nutrients and hormones control the activity of serine-arginine-rich proteins which regulate the splicing of G6PD mRNA.
Fri Jan 25 00:00:00 UTC 2013
Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.
The Journal of biological chemistry
Walsh CM,Suchanek AL,Cyphert TJ,Kohan AB,Szeszel-Fedorowicz W,Salati LM
33-9400 was used in ChIP assay and western blot to report that nutrients and hormones control the activity of serine-arginine-rich proteins which regulate the splicing of G6PD mRNA.
Fri Jan 25 00:00:00 UTC 2013
The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B.
RNA (New York, N.Y.)
Anderson ES,Lin CH,Xiao X,Stoilov P,Burge CB,Black DL
Tue May 01 00:00:00 UTC 2012
Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
Neurobiology of disease
Toiber D,Azkona G,Ben-Ari S,Torán N,Soreq H,Dierssen M
33-9400 was used in immunohistochemistry and western blot to assess the splicing machinery in Down syndrome brains
Fri Oct 01 00:00:00 UTC 2010
Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
Neurobiology of disease
Toiber D,Azkona G,Ben-Ari S,Torán N,Soreq H,Dierssen M
33-9400 was used in immunohistochemistry and western blot to assess the splicing machinery in Down syndrome brains
Fri Oct 01 00:00:00 UTC 2010
Changes in brain MicroRNAs contribute to cholinergic stress reactions.
Journal of molecular neuroscience : MN
Meerson A,Cacheaux L,Goosens KA,Sapolsky RM,Soreq H,Kaufer D
33-9400 was used in western blot to study how stress-regulated miRs regulate alternative splicing
Fri Jan 01 00:00:00 UTC 2010
RNA splicing capability of live neuronal dendrites.
Proceedings of the National Academy of Sciences of the United States of America
Glanzer J,Miyashiro KY,Sul JY,Barrett L,Belt B,Haydon P,Eberwine J
Tue Nov 15 00:00:00 UTC 2005
RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon.
Molecular and cellular biology
Buratti E,Muro AF,Giombi M,Gherbassi D,Iaconcig A,Baralle FE
Sun Feb 01 00:00:00 UTC 2004
RNA folding affects the recruitment of SR proteins by mouse and human polypurinic enhancer elements in the fibronectin EDA exon.
Molecular and cellular biology
Buratti E,Muro AF,Giombi M,Gherbassi D,Iaconcig A,Baralle FE
Sun Feb 01 00:00:00 UTC 2004
Cyclin L is an RS domain protein involved in pre-mRNA splicing.
The Journal of biological chemistry
Dickinson LA,Edgar AJ,Ehley J,Gottesfeld JM
33-9400 was used in Western Blot to report the cDNA cloning and functional characterisation of human cyclin L, a novel cyclin related to the C-type cyclines that are involved in regulation of RNA polymerase II transcription.
Fri Jul 12 00:00:00 UTC 2002
