Invitrogen

SSTR3 Monoclonal Antibody (7H8E5)

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SSTR3 Antibody (MA5-31915) in WB

Western blot analysis of SSTR3 in HeLa (1), PANC-1 (2), PC-12 (3),SK-N-SH (4), U937 (5) and HepG2 (6) cell lysate. Samples were incubated with SSTR3 monoclonal antibody (Product # MA5-31915) using a dilution of 1:500-1:2000.

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产品信息

MA5-31915

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

流式细胞分析 (Flow)

1:200-1:400

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

7H8E5

抗原

Purified recombinant fragment of human SSTR3 (AA: 1-43) expressed in E. coli.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2787538

产品详细信息

MA5-31915 has been tested in indirect ELISA.

靶标信息

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

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