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产品信息
H00026228-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
STAP1 (NP_036240.1, 1 a.a. approximately 295 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
靶标信息
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCR downstream signaling 1; BCR downstream-signaling protein 1; Docking protein BRDG1; Signal-transducing adaptor protein 1; STAP-1; Stem cell adaptor protein 1; stem cell adaptor protein STAP-1
基因别名: AI586015; BRDG1; STAP-1; STAP1
UniProt ID: (Human) Q9ULZ2, (Mouse) Q9JM90
Entrez Gene ID: (Human) 26228, (Mouse) 56792
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of gene expression
negative regulation of macrophage chemotaxis
negative regulation of phosphorylation
positive regulation of B cell receptor signaling pathway
positive regulation of phagocytosis, engulfment
cellular response to lipopolysaccharide
negative regulation of ruffle assembly
negative regulation of macrophage colony-stimulating factor signaling pathway
positive regulation of microglial cell activation
positive regulation of non-membrane spanning protein tyrosine kinase activity
negative regulation of microglial cell migration
positive regulation of microglial cell mediated cytotoxicity
positive regulation of actin cytoskeleton reorganization
positive regulation of signal transduction
myeloid cell differentiation
