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STARD3 Antibody (PA5-96802) in WB
Western blot analysis of STARD3 in extracts of various cell lines. Samples were incubated with STARD3 Polyclonal antibody (Product # PA5-96802) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
产品信息
PA5-96802
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 170-445 of human STARD3 (NP_0067953)
偶联物
形式
Liquid
浓度
0.86 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808604
产品详细信息
Immunogen sequence: DFKVLPQEAE EERWYLAAQV AVARGPLLFS GALSEGQFYS PPESFAGSDN ESDEEVAGKK SFSAQEREYI RQGKEATAVV DQILAQEENW KFEKNNEYGD TVYTIEVPFH GKTFILKTFL PCPAELVYQE VILQPERMVL WNKTVTACQI LQRVEDNTLI SYDVSAGAAG GVVSPRDFVN VRRIERRRDR YLSSGIATSH SAKPPTHKYV RGENGPGGFI VLKSASNPRV CTFVWILNTD LKGRLPRYLI HQSLAATMFE FAFHLRQRIS ELGARA; Positive Samples: Jurkat, SKOV3, MCF7, A-549, Mouse lung, Mouse brain, Mouse heart, Rat brain; Cellular Location: Late endosome membrane, Multi-pass membrane protein
靶标信息
The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; Protein CAB1; Protein ES 64; Protein MLN 64; StAR-related lipid transfer (START) domain containing 3; StAR-related lipid transfer domain containing 3; StAR-related lipid transfer protein 3; StARD3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related
基因别名: CAB1; Es64; MLN64; STARD3
UniProt ID: (Human) Q14849, (Mouse) Q61542
Entrez Gene ID: (Human) 10948, (Mouse) 59045, (Rat) 363675
