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产品信息
PA5-28897
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 34 and 333 of Human STK36
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546373
产品详细信息
Recommended positive controls: NT2D, IMR32, Jurkat, HeLa, mouse brain.
Predicted reactivity: Mouse (97%), Rat (96%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fused homolog; serine/threonine kinase 36 (fused homolog, Drosophila); Serine/threonine-protein kinase 36; STK36; testicular tissue protein Li 188
基因别名: 1700112N14Rik; B930045J24; FU; Fused; KIAA1278; mKIAA1278; STK36
UniProt ID: (Human) Q9NRP7, (Mouse) Q69ZM6
Entrez Gene ID: (Human) 27148, (Mouse) 269209
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
transcription factor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
epithelial cilium movement
protein phosphorylation
positive regulation of hh target transcription factor activity
brain development
post-embryonic development
cilium assembly
positive regulation of smoothened signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
multicellular organism development
phosphorylation
cell projection organization
