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STOML2/SLP-2 Antibody (AIP-002-200UL) in WB
Western blot analysis of human brain neuroblastoma SH-SY5Y (lanes 1 and 5), human prostate carcinoma DU 145 (lanes 2 and 6), human pancreatic carcinoma PANC-1 (lanes 3 and 7) and human acute lymphoblastic leukemia MOLT-4 (lanes 4 and 8): - 1-4. Anti-STOML2/SLP-2 Antibody (#AIP-002), (1:800).5-8. Anti-STOML2/SLP-2 Antibody , preincubated with STOML2/SLP-2 Blocking Peptide (#BLP-IP002).
产品信息
AIP-002-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EGTRESAINVAEGKK, corresponding to amino acid residues 208-222 of rat Stomatin-like protein 2, Intracellular
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EPB72-like 2; EPB72-like protein 2; Paraprotein target 7; Paratarg-7; SLP-2; stomatin (EPB72)-like 2; stomatin-like 2; Stomatin-like protein 2, mitochondrial
基因别名: 0610038F01Rik; HSPC108; MSLP2; SLP-2; SLP2; STOML2
UniProt ID: (Human) Q9UJZ1, (Mouse) Q99JB2, (Rat) Q4FZT0
Entrez Gene ID: (Human) 30968, (Mouse) 66592, (Rat) 298203
mitochondrial calcium ion transport
cellular calcium ion homeostasis
mitochondrion organization
lipid localization
positive regulation of mitochondrial membrane potential
interleukin-2 production
mitochondrial protein processing
CD4-positive, alpha-beta T cell activation
mitochondrial ATP synthesis coupled proton transport
T cell receptor signaling pathway
protein oligomerization
positive regulation of mitochondrial DNA replication
positive regulation of cardiolipin metabolic process
stress-induced mitochondrial fusion
mitochondrion localization
