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SUR2A Antibody (MA5-45607) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with SUR2A monoclonal antibody (Product # MA5-45607) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for 60 min RT, 5 min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (... View More
产品信息
MA5-45607
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
N319A/14
抗原
Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932061
产品详细信息
1 µg/mL of MA5-45607 was sufficient for detection of SUR2A in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 120kDa. Does not cross-react with SUR2B.
This antibody was formerly sold as clone S319A-14.
靶标信息
Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; FLJ36852; Sulfonylurea receptor 2; sulfonylurea-binding protein 2
基因别名: ABC37; ABCC9; AI414027; AI449286; ATFB12; CANTU; CMD1O; SUR2; SUR2A; SUR2B
UniProt ID: (Human) O60706, (Rat) Q63563, (Mouse) P70170
Entrez Gene ID: (Human) 10060, (Rat) 25560, (Mouse) 20928
transporter activity
potassium channel activity
ATP binding
sulfonylurea receptor activity
potassium channel regulator activity
anion transmembrane-transporting ATPase activity
ion channel binding
drug binding
syntaxin binding
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
potassium ion transport
signal transduction
potassium ion import
defense response to virus
transmembrane transport
anion transmembrane transport
regulation of cardiac conduction
substrate-dependent cell migration, cell contraction
metabolic process
response to drug
potassium ion transmembrane transport
transport
