Invitrogen

SWAP70 Polyclonal Antibody

图: 1 / 1

SWAP70 Antibody (PA1-41490) in WB

Western blot analysis of SWAP70 in Daudi cell lysate. Sample was incubated in SWAP70 polyclonal antibody (Product # PA1-41490).

Product Image Gallery

产品信息

PA1-41490

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-3 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues 300-350 of human SWAP-70.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein G

保存液

PBS with 0.2% gelatin

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2197048

产品详细信息

Suggested positive control: Daudi.

靶标信息

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.

仅用于科研。不用于诊断过程。未经明确授权不得转售。