Invitrogen

Saccharomyces cerevisiae ZIP1 Polyclonal Antibody

Saccharomyces cerevisiae ZIP1 Antibody in Western Blot (WB)

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Saccharomyces cerevisiae ZIP1 Antibody (PA5-117585) in WB

Western Blot analysis of ZIP1 using Saccharomyces cerevisiae ZIP1 Polyclonal Antibody (Product # PA5-117585) at 1:2,000. Positive WB detected in Recombinant protein. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 29 kDa. Observed band size: 43 kDa

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产品信息

PA5-117585

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

产品规格

种属反应

Yeast

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Saccharomyces cerevisiae Synaptonemal complex protein ZIP1 protein (1-227aa)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.95 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C or -80°C if preferred

运输条件

Wet ice

RRID

AB_2902214

产品详细信息

This antibody has been tested in direct-ELISA

靶标信息

ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

仅用于科研。不用于诊断过程。未经明确授权不得转售。