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Immunogen sequence: ETEDANEEAP LRDRSHIEKT LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR QHEITDGEIT SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QL
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 93%.
Sarcalumenin is a 160 kDa acidic calcium binding glycoprotein found to reside at the inner membrane of the sarcoplasmic reticulum in a calcium dependent manner. The gene encoding sarcalumenin also encodes an alternate splice variant, a 53 kDa glycoprotein which co-localizes with sarcalumenin. These two proteins are found in the longitudinal sarcoplasmic reticulum and the nonjunctional membranes of the terminal cisternae. They have been observed to co-localize with calcium-ATPase suggesting that they are involved in calcium transport and sequestration.
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