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Alomone Labs, LTD
Semaphorin 4D (SEMA4D) (extracellular) Polyclonal Antibody
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Semaphorin 4D (SEMA4D) (extracellular) Antibody (ASR-064-200UL) in WB
Western blot analysis of human Jurkat T-cell leukemia cell line lysate (lanes 1 and 3) and human HL-60 promyelocytic leukemia cell line lysate (lanes 2 and 4): - 1,2. Anti-Semaphorin-4D (SEMA4D) (extracellular) Antibody (#ASR-064), (1:200).3,4. Anti-Semaphorin-4D (SEMA4D) (extracellular) Antibody , preincubated with Semaphorin 4D/SEMA4D (extracellular) Blocking Peptide (#BLP-SR064).
产品信息
ASR-064-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EKQHEVYWKVSEDK, corresponding to amino acid residues 80-93 of mouse SEMA4D, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
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生物信息学
蛋白别名: A8; BB18; CD100; GR3; M-Sema G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Sema J; semaphorin H; Semaphorin-4D; Semaphorin-C-like 2; Semaphorin-J
基因别名: C9orf164; CD100; coll-4; M-sema-G; SEMA4D; Semacl2; SEMAJ; Semcl2
UniProt ID: (Human) Q92854, (Mouse) O09126
Entrez Gene ID: (Human) 10507, (Rat) 306790, (Mouse) 20354
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
immune response
cell adhesion
negative regulation of cell adhesion
regulation of cell shape
negative regulation of alkaline phosphatase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
regulation of cell projection organization
negative regulation of apoptotic process
positive regulation of GTPase activity
ossification involved in bone maturation
negative regulation of osteoblast differentiation
positive regulation of collateral sprouting
regulation of dendrite morphogenesis
negative regulation of axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
leukocyte aggregation
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
multicellular organism development
positive regulation of axonogenesis
nervous system development
cell differentiation
