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Product Details
PA5-77074
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human Serglycin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2720801
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gp600; hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; Hematopoietic proteoglycan core protein; Mastocytoma proteoglycan core protein; P.PG; Platelet proteoglycan core protein; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; proteoglycan, secretory granule; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; Serglycin; serglycin proteoglycan
Gene Aliases: PPG; PRG; PRG1; Sgc; SRGN
UniProt ID: (Human) P10124, (Mouse) P13609
Entrez Gene ID: (Human) 5552, (Mouse) 19073
apoptotic process
protein processing
biomineral tissue development
mast cell secretory granule organization
T cell secretory granule organization
maintenance of protease location in mast cell secretory granule
maintenance of granzyme B location in T cell secretory granule
negative regulation of cytokine secretion
platelet degranulation
granzyme-mediated apoptotic signaling pathway
negative regulation of bone mineralization
protease localization to mast cell secretory granule
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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