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Serglycin Antibody (MA5-43586) in IHC (P)
Immunohistochemistry of Serglycin in paraffin-embedded human spleen tissue. Samples were incubated in monoclonal Serglycin antibody (Product # MA5-43586) using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.
Product Details
MA5-43586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C1
Immunogen
Asp119-Gly148 (Accession P10124), with N-terminal His Tag
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2912520
Target Information
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chondroitin sulfate proteoglycan core protein; Cytolytic granule proteoglycan core protein; hematopoetic proteoglycan core peptide; hematopoetic proteoglycan core protein; Hematopoietic proteoglycan core protein; P.PG; PG19 core protein; Platelet proteoglycan core protein; proteoglycan 1, secretory granule; Proteoglycan 10K core protein; proteoglycan peptide core protein; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; Serglycin; serglycin proteoglycan
Gene Aliases: Pgsg; PPG; PRG; PRG1; SRGN
UniProt ID: (Human) P10124, (Rat) P04917
Entrez Gene ID: (Human) 5552, (Rat) 56782
platelet degranulation
granzyme-mediated apoptotic signaling pathway
protein processing
negative regulation of bone mineralization
biomineral tissue development
mast cell secretory granule organization
protease localization to mast cell secretory granule
T cell secretory granule organization
maintenance of protease location in mast cell secretory granule
maintenance of granzyme B location in T cell secretory granule
negative regulation of cytokine secretion
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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