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产品信息
325-MSM1-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
APCS, 3240
抗原
Recombinant fragment of human APCS protein (around aa 143-223)
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n; MGC88159; Pentaxin related; pentaxin-related; Pentraxin 2; pentraxin-2; pentraxin-related; PTX 2; SAMP; SAP; Serum amyloid P-component
基因别名: APCS; HEL-S-92n; PTX2; SAP
UniProt ID: (Human) P02743
Entrez Gene ID: (Human) 325
negative regulation of acute inflammatory response
protein folding
acute-phase response
cellular protein metabolic process
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
negative regulation of monocyte differentiation
negative regulation of viral entry into host cell
negative regulation of viral process
chaperone-mediated protein complex assembly
negative regulation of wound healing
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
