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NeoBiotechnologies
Sex Hormone Binding Globulin (SHBG) Recombinant Mouse Monoclonal Antibody (rSHBG-245)
产品信息
6462-MSM2-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
rSHBG-245
抗原
Recombinant full-length human SHBG protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human liver, placenta or testis. Cellular Localization: Cytoplasm. Extracellular (Secreted).
Specificity Comments: Recognizes a protein of 45kDa, identified as SHBG. It functions as an androgen transport protein, but may also be involved in receptor-mediated processes. Each dimer binds one molecule of steroid. It is specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
靶标信息
SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABP; Androgen binding protein (ABP); SBP; Sex hormone-binding globulin; Sex hormone-binding globulin (SHBG); Sex steroid binding protein (SBP); Sex steroid-binding protein; SHBG; TeBG; Testis-specific androgen-binding protein; Testosterone binding beta globulin; testosterone-binding beta-globulin; Testosterone-estradiol-binding globulin; Testosterone-Estradiol-Binding Globulin (TEBG); Testosterone-estrogen-binding globulin
基因别名: ABP; SBP; SHBG; TEBG
UniProt ID: (Human) P04278
Entrez Gene ID: (Human) 6462
