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Slc30A8 Antibody (PA5-119426) in WB
Western blot analysis of Slc30A8 in Lane 1: Wild-type K562 cell lysate; Lane 2: SLC30A8 knockout K562 cell lysate . Samples were incubated with polyclonal antibody (Product # PA5-119426) at a dilution of 3 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL.
产品信息
PA5-119426
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Solute Carrier Family 30 Member 8. The antigen corresponds to amino acid range 263-369 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903924
靶标信息
Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Proton-coupled zinc antiporter SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8
基因别名: SLC30A8; ZnT-8; ZNT8
UniProt ID: (Human) Q8IWU4
Entrez Gene ID: (Human) 169026
zinc II ion transport
cellular zinc ion homeostasis
response to glucose
response to zinc ion
insulin secretion
positive regulation of insulin secretion
sequestering of zinc ion
response to interferon-gamma
glucose homeostasis
regulation of vesicle-mediated transport
regulation of sequestering of zinc ion
response to interleukin-1
zinc II ion transmembrane transport
