Invitrogen

Sorcin Polyclonal Antibody

查看其他10个Sorcin抗体

抗体检测数据 (3)

Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Sorcin Antibody (PA5-98174) in IHC (P)

Immunohistochemical analysis of Sorcin in paraffin embedded human small intestine tissue using a Sorcin polyclonal antibody (Product # PA5-98174) at a dilution of 1:100.

Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Sorcin Antibody in Western Blot (WB)

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Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Sorcin in paraffin embedded human small intestine tissue using a Sorcin polyclonal antibody (Product # PA5-98174) at a dilution of 1:100.

Sorcin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Sorcin in paraffin embedded human liver tissue using a Sorcin polyclonal antibody (Product # PA5-98174) at a dilution of 1:100.

Sorcin Antibody in Western Blot (WB) — Western Blot analysis of Sorcin using a Sorcin Polyclonal antibody (Product # PA5-98174) at a concentration of 2 µg/mL. Lane 1: HepG2 whole cell lysate. Lane 2: Hela whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 22 kDa.

产品信息

PA5-98174

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:1,000

-

免疫组化（石蜡） (IHC (P))

1:20-1:200

-

酶联免疫吸附实验 (ELISA)

Assay-Dependent

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human Sorcin protein (1-198AA)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.21 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C or -80°C if preferred

运输条件

Wet ice

AB_2812788

靶标信息

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells; CP-22; CP22; H_RG167B05.1; Sorcin; V19

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基因别名: CP-22; CP22; SCN; SRI; V19

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UniProt ID: (Human) P30626

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Entrez Gene ID: (Human) 6717

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protease binding calcium-dependent cysteine-type endopeptidase activity receptor binding calcium channel regulator activity calcium ion binding protein binding ion channel binding protein heterodimerization activity repressing transcription factor binding actin or actin-binding cytoskeletal protein

action potential proteolysis transport calcium ion transport intracellular sequestering of iron ion regulation of striated muscle contraction signal transduction heart development muscle organ development regulation of heart contraction negative regulation of heart rate regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of insulin secretion involved in cellular response to glucose stimulus cytoplasmic sequestering of transcription factor positive regulation of release of sequestered calcium ion into cytosol regulation of calcium ion transport negative regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction regulation of relaxation of muscle regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of transcription regulatory region DNA binding