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产品信息
PA5-110427
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human alpha 1 Spectrin (NP_0031172)
偶联物
形式
Liquid
浓度
2.48 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855838
产品详细信息
Immunogen sequence: KHEAFLLDLN SFGDSMKALR NQANACQQQQ AAPVEGVAGE QRVMALYDFQ ARSPREVTMK KGDVLTLLSS INKDWWKVEA ADHQGIVPAV YVRRLAHDEF PMLPQRRREE PGNITQRQEQ IENQYRSLLD RAEERRRRLL QRYNEFLLAY EAGDMLEWIQ EKKAENTGVE LDDVWELQKK FDEFQKDLNT NEPRLRDINK VADDLLFEGL LTPEGAQIRQ E
靶标信息
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-I spectrin; alpha-spectrin 1, erythroid; elliptocytosis 2; Erythroid alpha-spectrin; erythroid spectrin alpha; hemolytic anemia; mutant alpha spectrin; neuroscience mutagenesis facility, 4; spectrin alpha 1; spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spherocytosis
基因别名: AF093576; AI451697; EL2; ha; HPP; HS3; ihj; nmf4; sph; SPH3; Spna-1; Spna1; SPTA; SPTA1
UniProt ID: (Human) P02549, (Mouse) P08032
Entrez Gene ID: (Human) 6708, (Rat) 289257, (Mouse) 20739
MAPK cascade
lymphocyte homeostasis
porphyrin-containing compound biosynthetic process
ER to Golgi vesicle-mediated transport
plasma membrane organization
actin filament organization
axon guidance
regulation of cell shape
hemopoiesis
positive regulation of protein binding
positive regulation of T cell proliferation
positive regulation of GTPase activity
actin filament capping
biological_process
actin cytoskeleton organization
