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产品信息
6712-MSM3-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
SPTBN2, 1583
抗原
Recombinant fragment (around aa356-475) of human SPTBN2 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
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生物信息学
蛋白别名: Beta-III spectrin; glutamate transporter EAAT4-associated protein 41; Spectrin Beta; spectrin beta chain, brain 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; Spinocerebellar ataxia 5 protein
基因别名: GTRAP41; KIAA0302; SCA5; SCAR14; SPTBN2
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712
MAPK cascade
ER to Golgi vesicle-mediated transport
cytoskeleton organization
axon guidance
synapse assembly
vesicle-mediated transport
antigen processing and presentation of exogenous peptide antigen via MHC class II
cerebellar Purkinje cell layer morphogenesis
adult behavior
multicellular organism growth
positive regulation of GTPase activity
actin filament capping
cellular response to ethanol
cell-cell adhesion
