NeoBiotechnologies

Steroidogenic Factor 1 (SF-1) (Transcription Factor) Monoclonal Antibody (NR5A1/3420)

Steroidogenic Factor 1 (SF-1) (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Steroidogenic Factor 1 (SF-1) (Transcription Factor) Antibody (2516-MSM6-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human testis stained with SF-1 Mouse Monoclonal Antibody (NR5A1/3420) at 2 µg/mL. Inset: PBS instead of primary antibody; secondary only negative control.

Steroidogenic Factor 1 (SF-1) (Transcription Factor) Antibody in Peptide array (ARRAY)

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产品信息

2516-MSM6-P1

应用

建议稀释比

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免疫组化（石蜡） (IHC (P))

1-2 µg/mL

肽阵列 (Array)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

NR5A1/3420

抗原

Recombinant fragment (around aa220-461) of human SF-1 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: Human testis or adrenal cortical carcinoma. Cellular Localization: Nucleus.

Specificity Comments: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Steroidogenic Factor 1 (SF-1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development. SF-1 is highly valuable marker to determine the adrenocortical origin of an adrenal mass.

靶标信息

Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adrenal 4 binding protein; Adrenal 4 binding protein (AD4BP); Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Fushi tarazu factor homolog 1 (FTZ1); nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; Nuclear receptor subfamily 5 group A member 1 (NR5A1); nuclear receptor subfamily 5, group A, member 1; SF-1; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; Steroidogenic factor 1 (SF1); steroidogenic factor 1 nuclear receptor; steroidogenic factor-1; STF-1; STF1

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基因别名: AD4BP; ELP; FTZ1; FTZF1; hSF-1; NR5A1; POF7; SF-1; SF1; SPGF8; SRXY3

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UniProt ID: (Human) Q13285

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Entrez Gene ID: (Human) 2516

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